Vol. 7, Issue 1, Part A (2025)

Computed tomography (CT) examinations are essential in modern diagnostic radiology. However, the ionizing radiation associated with CT imaging poses potential risks, including oxidative stress in biological systems. This paper investigates the oxidative effects of radiation-induced CT on human blood samples, focusing on the generation of reactive oxygen species (ROS), changes in antioxidant defense mechanisms, and their implications for patient health.

Studying the impact of patient blood samples exposed to varying x-ray doses on the ionized radiation from the computed tomography scan (CT-scan). Blood samples were analysed by electrochemical analysis using a cyclic redox voltammetric device to detect oxidative stress from both the contrast agent (iodine solution) and ionize radiation. It was chosen 40 patients divided into 20 females and 20 males with the range of age from 30 to 60 years. Ten of patients were control samples without any exposed to the x ray of CT-scan type Toshiba Aquilion (64 slice), the other 30 patients were divided into three groups;10 patients exposed with different doses radiation (150-520 rem unit) using without contrast medium, 10 patients with contrast medium (Iodine solution) and exposed with the same different doses of radiation by computed tomography. The other 10 patients with contrast medium and with ascorbic acid (AA) to study the impact of ascorbic acid as anti-oxidative effect on the exposed patient blood samples with contrast medium. The results illustrated that the patient blood samples exposed to different doses of ionized radiation of CT-scan were enhanced the oxidative stress of the blood composition, which increases with the presence of contrast material. Also, it was used ascorbic acid which act as anti-oxidative stress to the blood with and without contrast medium. It can be concluded that the ionize radiation of CT-scan caused a high oxidative stress of the blood composition with and without contrast medium, but when used ascorbic acid the oxidation stress was inhibited by these anti-oxidative reagents (AA).